Two precise, simple, accurate, reproducible, rapid and economical UV spectrophotometric methods have been developed for simultaneous estimation of norfloxacin and loperamide in capsule dosage form by using 0.1M methanolic HCl as a solvent. Method I is based on simultaneous equation method, known as vierodt’s method. Norfloxacin and loperamide show absorbance maxima at 277 nm and 259 nm respectively. Method II is based on principle of Q-analysis, known as absorbance ratio method in which absorbance of both drugs was measured at 268 nm (Isobestic point) and 277 nm (λmax of norfloxacin). Norfloxacin and loperamide obeys Beer’s law in the concentration range of 5 to 30 µg/ml and 10 to 60 µg/ml respectively. Both methods are validated according to ICH guidelines and can be applied for routine analysis of these drugs in capsule dosage form.
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